Isopropyl iodide → HCID 86724162, compound

HRID 873050Notes

Reaction equation

HRID 873050 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[NH:11][CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.I[CH:13]([CH3:15])[CH3:14].C([O-])([O-])=O.[Cs+].[Cs+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]2[N:11]([CH:13]([CH3:15])[CH3:14])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1

Participants

5

Reactant 3

HCID 6362Isopropyl iodideHCID 10796Cesium carbonateHCID 135743575HCID 135743575, compound

Product 1

HCID 86724162HCID 86724162, compoundYield 53.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 7-chloro-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (700 mg, 4.08 mol), 2-iodopropane (1.04 g, 6.12 mmol) and Cs2CO3 (2.66 g, 8.16 mmol) in acetonitrile (15 mL) was refluxed for 3 h, filtered and concentrated to remove solvent to get crude product (700 mg) without further purification.

Workup

  1. temperaturewas refluxed for 3 h
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customto remove solvent

Sources & evidence

ORD record
ord-eefb52ef16654f9bbc878df88682ece4
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

Loading…