Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 873074Generated: October 27, 2026

Sodium hydride → tert-butyl 7-((3-cyano-4-(4-cyano-3-(trifluoromethyl)phenoxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

https://huagongshe.com/reaction/873074

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
Reactant4-(2-Cyano-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrileHCID 71240012—
ReactantTert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylateHCID 71743561—
Producttert-butyl 7-((3-cyano-4-(4-cyano-3-(trifluoromethyl)phenoxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylateHCID 71240896—

Reaction Steps

The title compound was prepared by a procedure similar to that described for E1 starting from NaH, 4-(2-cyano-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrile and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08975400B2
Source datasetuspto-grants-2015_03
ORD IDord-7fb55e563675468aa5d798793b6a9890
Source noteuspto-grants-2015_03