Sodium hydride → tert-butyl 7-((3-cyano-4-(4-cyano-3-(trifluoromethyl)phenoxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

HRID 873074Notes

Reaction equation

HRID 873074 reaction equation
[H-].[Na+].[C:3]([C:5]1[CH:23]=[C:22]([CH2:24][OH:25])[CH:21]=[CH:20][C:6]=1[O:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:9]=1)#[N:4].Cl[C:27]1[CH:28]=[C:29]2[N:36]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH2:35][CH2:34][N:30]2[C:31](=[O:33])[N:32]=1>>[C:3]([C:5]1[CH:23]=[C:22]([CH:21]=[CH:20][C:6]=1[O:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:18])([F:17])[F:19])[CH:9]=1)[CH2:24][O:25][C:27]1[CH:28]=[C:29]2[N:36]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH2:35][CH2:34][N:30]2[C:31](=[O:33])[N:32]=1)#[N:4]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 712400124-(2-Cyano-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrileHCID 71743561Tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylate

Product 1

HCID 71240896tert-butyl 7-((3-cyano-4-(4-cyano-3-(trifluoromethyl)phenoxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from NaH, 4-(2-cyano-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrile and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Sources & evidence

ORD record
ord-7fb55e563675468aa5d798793b6a9890
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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