HRID873074

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

结构：N#Cc1cc(CO)ccc1Oc1ccc(C#N)c(C(F)(F)F)c1

HCID71240012

未命名化合物

HCID71743561

Imidazo[1,2-c]pyrimidine-1(5H)-carboxylic acid, 7-chloro-2,3-dihydro-5-oxo-, 1,1-dimethylethyl ester

C11H14ClN3O3

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCn2c1cc(OCc1ccc(Oc3ccc(C#N)c(C(F)(F)F)c3)c(C#N)c1)nc2=O

HCID71240896

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by a procedure similar to that described for E1 starting from NaH, 4-(2-cyano-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrile and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7fb55e563675468aa5d798793b6a9890
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08975400B2
来源说明: uspto-grants-2015_03

反应 SMILES

[H-].[Na+].[C:3]([C:5]1[CH:23]=[C:22]([CH2:24][OH:25])[CH:21]=[CH:20][C:6]=1[O:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:9]=1)#[N:4].Cl[C:27]1[CH:28]=[C:29]2[N:36]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH2:35][CH2:34][N:30]2[C:31](=[O:33])[N:32]=1>>[C:3]([C:5]1[CH:23]=[C:22]([CH:21]=[CH:20][C:6]=1[O:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:18])([F:17])[F:19])[CH:9]=1)[CH2:24][O:25][C:27]1[CH:28]=[C:29]2[N:36]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH2:35][CH2:34][N:30]2[C:31](=[O:33])[N:32]=1)#[N:4]