Sodium hydride → tert-butyl 7-((4-(3,4-dichlorophenoxy)-3-fluorobenzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

HRID 873089Notes

Reaction equation

HRID 873089 reaction equation
[H-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][C:19]=1[Cl:20])[O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][OH:15])=[CH:10][C:9]=1[F:16].Cl[C:22]1[CH:23]=[C:24]2[N:31]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH2:30][CH2:29][N:25]2[C:26](=[O:28])[N:27]=1>>[Cl:3][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][C:19]=1[Cl:20])[O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][O:15][C:22]2[CH:23]=[C:24]3[N:31]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH2:30][CH2:29][N:25]3[C:26](=[O:28])[N:27]=2)=[CH:10][C:9]=1[F:16]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 54898336(4-(3,4-Dichlorophenoxy)-3-fluorophenyl)methanolHCID 71743561Tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylate

Product 1

HCID 71243763tert-butyl 7-((4-(3,4-dichlorophenoxy)-3-fluorobenzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from NaH, (4-(3,4-dichlorophenoxy)-3-fluorophenyl)methanol and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Sources & evidence

ORD record
ord-2cfe798ad2844eccb94c6cce7198a59e
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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