Sodium hydride → HCID 71241024, compound

HRID 873096Notes

Reaction equation

HRID 873096 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([O:9][C:10]2[CH:17]=[CH:16][C:15]([CH2:18][OH:19])=[CH:14][C:11]=2[C:12]#[N:13])[CH:5]=[N:6][C:7]=1[F:8].[H-].[Na+].Cl[C:23]1[CH:24]=[C:25]2[N:32]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1>>[C:12]([C:11]1[CH:14]=[C:15]([CH:16]=[CH:17][C:10]=1[O:9][C:4]1[CH:5]=[N:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=1)[CH2:18][O:19][C:23]1[CH:24]=[C:25]2[N:32]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1)#[N:13]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 71240182HCID 71240182, compoundHCID 71743561Tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylate

Product 1

HCID 71241024HCID 71241024, compound

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from 2-((5,6-difluoropyridin-3-yl)oxy)-5-(hydroxymethyl)benzonitrile, NaH and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Sources & evidence

ORD record
ord-c70a41d1e9d24be491cc153ac777a575
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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