Sodium hydride → tert-butyl 7-((3-cyano-4-(3-fluoro-5-(trifluoromethyl)phenoxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

HRID 873100Notes

Reaction equation

HRID 873100 reaction equation
[H-].[Na+].[F:3][C:4]1[CH:5]=[C:6]([CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1)[O:7][C:8]1[CH:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12][C:9]=1[C:10]#[N:11].Cl[C:26]1[CH:27]=[C:28]2[N:35]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[CH2:34][CH2:33][N:29]2[C:30](=[O:32])[N:31]=1>>[C:10]([C:9]1[CH:12]=[C:13]([CH:14]=[CH:15][C:8]=1[O:7][C:6]1[CH:18]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:20]=[C:4]([F:3])[CH:5]=1)[CH2:16][O:17][C:26]1[CH:27]=[C:28]2[N:35]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[CH2:34][CH2:33][N:29]2[C:30](=[O:32])[N:31]=1)#[N:11]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 712396162-(3-Fluoro-5-(trifluoromethyl)phenoxy)-5-(hydroxymethyl)benzonitrileHCID 71743561Tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylate

Product 1

HCID 86724176tert-butyl 7-((3-cyano-4-(3-fluoro-5-(trifluoromethyl)phenoxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from NaH, 2-(3-fluoro-5-(trifluoromethyl)phenoxy)-5-(hydroxymethyl)benzonitrile and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Sources & evidence

ORD record
ord-33c6ae527cea43dea79750426d65a59c
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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