3,4-Difluorobenzaldehyde → 2-Fluoro-5-(2-fluoro-4-formylphenoxy)benzonitrile

HRID 873114Notes

Reaction equation

HRID 873114 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1F)[CH:5]=[O:6].[F:11][C:12]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][C:13]=1[C:14]#[N:15]>>[F:11][C:12]1[CH:19]=[CH:18][C:17]([O:20][C:9]2[CH:8]=[CH:7][C:4]([CH:5]=[O:6])=[CH:3][C:2]=2[F:1])=[CH:16][C:13]=1[C:14]#[N:15]

Participants

3

Reactant 2

HCID 5880883,4-DifluorobenzaldehydeHCID 226124102-Fluoro-5-hydroxybenzonitrile

Product 1

HCID 867241812-Fluoro-5-(2-fluoro-4-formylphenoxy)benzonitrile

Procedure

The title compound was prepared by a procedure similar to that described for D4 starting from 3,4-difluorobenzaldehyde (188 mg, 1.32 mmol) and 2-fluoro-5-hydroxybenzonitrile.

Sources & evidence

ORD record
ord-aa11a3eb89f34b9f8d33a2fa07c214d7
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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