Sodium hydride → HCID 71243753, compound

HRID 873121Notes

Reaction equation

HRID 873121 reaction equation
[H-].[Na+].[OH:3][CH2:4][C:5]1[CH:19]=[CH:18][C:8]([O:9][C:10]2[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=2)[C:13]#[N:14])=[C:7]([C:20]([F:23])([F:22])[F:21])[CH:6]=1.[C:24]([O:28][C:29]([N:31]1[C:39]2[N:34]([C:35](=[O:41])[N:36]=[C:37](Cl)[CH:38]=2)[CH2:33][CH2:32]1)=[O:30])([CH3:27])([CH3:26])[CH3:25]>>[C:13]([C:12]1[CH:11]=[C:10]([CH:17]=[CH:16][CH:15]=1)[O:9][C:8]1[CH:18]=[CH:19][C:5]([CH2:4][O:3][C:37]2[CH:38]=[C:39]3[N:31]([C:29]([O:28][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:30])[CH2:32][CH2:33][N:34]3[C:35](=[O:41])[N:36]=2)=[CH:6][C:7]=1[C:20]([F:21])([F:22])[F:23])#[N:14]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 71239822HCID 71239822, compoundHCID 71743561Tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylate

Product 1

HCID 71243753HCID 71243753, compound

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from NaH, 3-(4-(hydroxymethyl)-2-(trifluoromethyl)phenoxy)benzonitrile and tert-butyl-7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Sources & evidence

ORD record
ord-ce7a63cf5477454e8f826ef605ef243b
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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