(4-(3,4-Difluorophenoxy)-3-fluorophenyl)methanol → 7-((4-(3,4-difluorophenoxy)-3-fluorobenzyl)oxy)-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 873175Notes

Reaction equation

HRID 873175 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[F:13][C:14]1[CH:15]=[C:16]([CH:27]=[CH:28][C:29]=1[F:30])[O:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][OH:25])=[CH:20][C:19]=1[F:26]>>[F:13][C:14]1[CH:15]=[C:16]([CH:27]=[CH:28][C:29]=1[F:30])[O:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][O:25][C:2]2[CH:3]=[C:4]3[N:11]([CH3:12])[CH2:10][CH2:9][N:5]3[C:6](=[O:8])[N:7]=2)=[CH:20][C:19]=1[F:26]

Participants

3

Reactant 2

HCID 43554868(4-(3,4-Difluorophenoxy)-3-fluorophenyl)methanolHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 712409237-((4-(3,4-difluorophenoxy)-3-fluorobenzyl)oxy)-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Procedure

The title compound was prepared by a procedure similar to those described for E1 starting from 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one and (4-(3,4-difluorophenoxy)-3-fluorophenyl)methanol.

Sources & evidence

ORD record
ord-d7bd313f9bb64a4dafa5f8fd88941af2
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

Loading…