HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 7-((3,5-difluoro-4-(4-fluorophenoxy)benzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl 7-((3,5-difluoro-4-(4-fluorophenoxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate | HCID 71243749 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-((3,5-difluoro-4-(4-fluorophenoxy)benzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one | HCID 71243773 | — |
Reaction Steps
Prepared in a manner similar to that described for E60 using tert-butyl 7-((3,5-difluoro-4-(4-fluorophenoxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carbo-xylate (150 mg, 0.306 mmol) and TFA (2 mL, 26.0 mmol) in DCM (10 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975400B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-26d379e2ea1c4295b2f60a48ea2fd8be |
| Source note | uspto-grants-2015_03 |