Trifluoroacetic acid → 7-((3,5-difluoro-4-(4-fluorophenoxy)benzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 873195Notes

Reaction equation

HRID 873195 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:24]=[C:25]([F:35])[C:26]=1[O:27][C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1)[CH2:5][O:6][C:7]1[CH:8]=[C:9]2[N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14][N:10]2[C:11](=[O:13])[N:12]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:24]=[C:25]([F:35])[C:26]=1[O:27][C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1)[CH2:5][O:6][C:7]1[CH:8]=[C:9]2[NH:16][CH2:15][CH2:14][N:10]2[C:11](=[O:13])[N:12]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71243749tert-butyl 7-((3,5-difluoro-4-(4-fluorophenoxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

Product 1

HCID 712437737-((3,5-difluoro-4-(4-fluorophenoxy)benzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared in a manner similar to that described for E60 using tert-butyl 7-((3,5-difluoro-4-(4-fluorophenoxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carbo-xylate (150 mg, 0.306 mmol) and TFA (2 mL, 26.0 mmol) in DCM (10 mL).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-26d379e2ea1c4295b2f60a48ea2fd8be
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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