Trifluoroacetic acid → HCID 71241004, compound

HRID 873209Notes

Reaction equation

HRID 873209 reaction equation
[Cl:1][C:2]1[CH:35]=[CH:34][C:5]([O:6][C:7]2[CH:31]=[CH:30][C:10]([CH2:11][O:12][C:13]3[CH:14]=[C:15]4[N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20][N:16]4[C:17](=[O:19])[N:18]=3)=[CH:9][C:8]=2[C:32]#[N:33])=[CH:4][C:3]=1[C:36]([F:39])([F:38])[F:37].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:35]=[CH:34][C:5]([O:6][C:7]2[CH:31]=[CH:30][C:10]([CH2:11][O:12][C:13]3[CH:14]=[C:15]4[NH:22][CH2:21][CH2:20][N:16]4[C:17](=[O:19])[N:18]=3)=[CH:9][C:8]=2[C:32]#[N:33])=[CH:4][C:3]=1[C:36]([F:39])([F:38])[F:37]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71241187HCID 71241187, compound

Product 1

HCID 71241004HCID 71241004, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared in a manner similar to that described for E60 using tert-butyl 7-((4-(4-chloro-3-(trifluoromethyl)phenoxy)-3-cyanobenzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyri-midine-1(5H)-carboxylate (150 mg, 0.266 mmol) and TFA (5 ml, 64.9 mmol) in DCM (5 mL).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-4db9ffedc37d44318afcb68fbc74e5fe
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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