HCID 71243751, compound → HCID 71243794, compound

HRID 873222Notes

Reaction equation

HRID 873222 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[O:27][C:28]1[CH:33]=[CH:32][C:31]([F:34])=[C:30]([F:35])[CH:29]=1)[CH2:5][O:6][C:7]1[CH:8]=[C:9]2[N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14][N:10]2[C:11](=[O:13])[N:12]=1>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[O:27][C:28]1[CH:33]=[CH:32][C:31]([F:34])=[C:30]([F:35])[CH:29]=1)[CH2:5][O:6][C:7]1[CH:8]=[C:9]2[NH:16][CH2:15][CH2:14][N:10]2[C:11](=[O:13])[N:12]=1

Participants

3

Reactant 1

HCID 71243751HCID 71243751, compound

Product 1

HCID 71243794HCID 71243794, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E60 using tert-butyl 7-((3-chloro-4-(3,4-difluorophenoxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1 (5H)-carboxylate (50 mg, 0.099 mmol) in DMF (2 mL) and silica gel (150 mg).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-c9068c7156f647b9bc6d52da68d3880d
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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