Sodium hydride → HCID 71243732, compound

HRID 873228Notes

Reaction equation

HRID 873228 reaction equation
[H-].[Na+].[F:3][C:4]([F:21])([F:20])[C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][OH:19])=[CH:14][CH:13]=2)[CH:8]=[CH:7][N:6]=1.Cl[C:23]1[CH:24]=[C:25]2[N:32]([CH3:33])[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1>>[CH3:33][N:32]1[C:25]2[N:26]([C:27](=[O:29])[N:28]=[C:23]([O:19][CH2:18][C:15]3[CH:16]=[CH:17][C:12]([O:11][C:9]4[CH:8]=[CH:7][N:6]=[C:5]([C:4]([F:3])([F:20])[F:21])[CH:10]=4)=[CH:13][CH:14]=3)[CH:24]=2)[CH2:30][CH2:31]1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 71240244HCID 71240244, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71243732HCID 71243732, compound

Procedure

Prepared in a manner similar to that described for E1 using sodium hydride (4.85 mg, 0.121 mmol), (4-((2-(trifluoromethyl)pyridin-4-yl)oxy)phenyl)methanol (35 mg, 0.130 mmol) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (24.13 mg, 0.130 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-8ca46d035f8c47678f2477b5435d7088
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

Loading…