Sodium hydride → HCID 71243761, compound

HRID 873229Notes

Reaction equation

HRID 873229 reaction equation
[H-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH:16]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:18]=1)[O:7][C:8]1[N:13]=[CH:12][C:11]([CH2:14][OH:15])=[CH:10][CH:9]=1.Cl[C:24]1[CH:25]=[C:26]2[N:33]([CH3:34])[CH2:32][CH2:31][N:27]2[C:28](=[O:30])[N:29]=1>>[Cl:3][C:4]1[CH:5]=[C:6]([CH:16]=[C:17]([C:19]([F:20])([F:22])[F:21])[CH:18]=1)[O:7][C:8]1[N:13]=[CH:12][C:11]([CH2:14][O:15][C:24]2[CH:25]=[C:26]3[N:33]([CH3:34])[CH2:32][CH2:31][N:27]3[C:28](=[O:30])[N:29]=2)=[CH:10][CH:9]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 71239729HCID 71239729, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71243761HCID 71243761, compound

Procedure

Prepared in a manner similar to that described for E1 using sodium hydride (4.85 mg, 0.121 mmol), (6-(3-chloro-5-(trifluoromethyl)phenoxy)pyridin-3-yl)methanol (60 mg, 0.198 mmol) in THEF (8 mL) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (36.7 mg, 0.198 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-7b082cefe3a64b8fb090e9825f4694b6
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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