Trifluoroacetic acid → HCID 71241130, compound

HRID 873232Notes

Reaction equation

HRID 873232 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH2:20][O:21][C:22]2[CH:23]=[C:24]3[N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29][N:25]3[C:26](=[O:28])[N:27]=2)[CH:6]=[N:7][C:8]=1[O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=1)#[N:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:28]=[C:26]1[N:25]2[CH2:29][CH2:30][NH:31][C:24]2=[CH:23][C:22]([O:21][CH2:20][C:5]2[CH:6]=[N:7][C:8]([O:9][C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:17])([F:18])[F:19])[CH:11]=3)=[C:3]([CH:4]=2)[C:1]#[N:2])=[N:27]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71243764HCID 71243764, compound

Product 1

HCID 71241130HCID 71241130, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared in a manner similar to that described for E60 using tert-butyl 7-((5-cyano-6-(3-(trifluoromethyl)phenoxy)pyridin-3-yl)methoxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate (120 mg, 0.227 mmol) in DCM (4 mL) and TFA (0.873 mL, 11.3 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-e45d103328c34aa3b1748b2c7bf084a9
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

Loading…