Trifluoroacetic acid → O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Participants

Reaction Conditions

Reaction Steps

N-t-Butoxycarbonyl-O-(mesitylsulfonyl)hydroxylamine (4.0 g) was added to TFA (15 mL) at 0° C., and the mixture was stirred for 1 h at 0° C. The reaction mixture was poured into ice water (100 mL) and the precipitate collected by filtration. The solid was dissolved in the minimum volume of ether and precipitated by the addition of three to four times the volume of petroleum ether 40-60. The mixture was cooled to 0° C. and stirred for 15 min Filtration yielded O-(Mesitylsulfonyl)hydroxylamine (Intermediate 2) as a solid.

Provenance & Evidence