反应详情

温度

0 °C

N-t-Butoxycarbonyl-O-(mesitylsulfonyl)hydroxylamine (4.0 g) was added to TFA (15 mL) at 0° C., and the mixture was stirred for 1 h at 0° C. The reaction mixture was poured into ice water (100 mL) and the precipitate collected by filtration. The solid was dissolved in the minimum volume of ether and precipitated by the addition of three to four times the volume of petroleum ether 40-60. The mixture was cooled to 0° C. and stirred for 15 min Filtration yielded O-(Mesitylsulfonyl)hydroxylamine (Intermediate 2) as a solid.

1. filtrationthe precipitate collected by filtration
2. dissolutionThe solid was dissolved in the minimum volume of ether
3. customprecipitated by the addition of three to four times the volume of petroleum ether 40-60
4. temperatureThe mixture was cooled to 0° C.
5. stirringstirred for 15 min
6. filtrationFiltration