反应详情

5-Bromo-3-fluoropicolinamide (1.44 g, 6.5 mmol) was stirred at 120° C. in conc. HCl (17 mL) for 1.5 h. The mixture was cooled in an ice bath and the pH adjusted to pH 5 with NaOH solution (48%, aq.). The mixture was extracted with 40% MeOH in DCM, dried using a phase separator and concentrated in vacuo to give a brown powder.

1. temperatureThe mixture was cooled in an ice bath
2. extractionThe mixture was extracted with 40% MeOH in DCM
3. customdried
4. concentrationconcentrated in vacuo
5. customto give a brown powder