HRID873563

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CCC(Oc2ccc(C(=O)O)cc2)CC1

HCID2794649

4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}benzoic acid

C17H23NO5

HCID10988214

1-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acid

C12H13NO4

HCID22181157

tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

C16H24N2O3

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(Oc2ccc(C(=O)NC3CN(C(=O)OCc4ccccc4)C3)cc2)CC1

HCID86702039

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as described in Example 1A, substituting benzyl 3-aminoazetidine-1-carboxylate for tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate and 4-(1-(tert-butoxycarbonyl)piperidin-4-yloxy)benzoic acid for 1-(benzyloxycarbonyl)azetidine-3-carboxylic acid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-125423e8e4834e758f512ca799f8cada
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08975398B2
来源说明: uspto-grants-2015_03

反应 SMILES

N[C:2]1[CH:21]=[CH:20][C:5]([O:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.C([O:26][C:27]([N:29]1CCC(OC2C=CC(C(O)=O)=CC=2)CC1)=O)(C)(C)C.[CH2:45]([O:52][C:53]([N:55]1[CH2:58][CH:57](C(O)=O)[CH2:56]1)=[O:54])[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1>>[CH2:45]([O:52][C:53]([N:55]1[CH2:56][CH:57]([NH:29][C:27]([C:2]2[CH:21]=[CH:20][C:5]([O:6][CH:7]3[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9][CH2:8]3)=[CH:4][CH:3]=2)=[O:26])[CH2:58]1)=[O:54])[C:46]1[CH:47]=[CH:48][CH:49]=[CH:50][CH:51]=1