4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}benzoic acid → Tert-butyl 4-(4-(1-(benzyloxycarbonyl)azetidin-3-ylcarbamoyl)phenoxy)piperidine-1-carboxylate

HRID 873563Notes

Reaction equation

HRID 873563 reaction equation
N[C:2]1[CH:21]=[CH:20][C:5]([O:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.C([O:26][C:27]([N:29]1CCC(OC2C=CC(C(O)=O)=CC=2)CC1)=O)(C)(C)C.[CH2:45]([O:52][C:53]([N:55]1[CH2:58][CH:57](C(O)=O)[CH2:56]1)=[O:54])[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1>>[CH2:45]([O:52][C:53]([N:55]1[CH2:56][CH:57]([NH:29][C:27]([C:2]2[CH:21]=[CH:20][C:5]([O:6][CH:7]3[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9][CH2:8]3)=[CH:4][CH:3]=2)=[O:26])[CH2:58]1)=[O:54])[C:46]1[CH:47]=[CH:48][CH:49]=[CH:50][CH:51]=1

Participants

4

Reactant 3

HCID 27946494-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}benzoic acidHCID 109882141-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acidHCID 22181157tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

Product 1

HCID 86702039Tert-butyl 4-(4-(1-(benzyloxycarbonyl)azetidin-3-ylcarbamoyl)phenoxy)piperidine-1-carboxylate

Procedure

The title compound was prepared as described in Example 1A, substituting benzyl 3-aminoazetidine-1-carboxylate for tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate and 4-(1-(tert-butoxycarbonyl)piperidin-4-yloxy)benzoic acid for 1-(benzyloxycarbonyl)azetidine-3-carboxylic acid.

Sources & evidence

ORD record
ord-125423e8e4834e758f512ca799f8cada
Source dataset
uspto-grants-2015_03
Patent number
US08975398B2

Reaction notes

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