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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 873563Generated: October 30, 2026

4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}benzoic acid → Tert-butyl 4-(4-(1-(benzyloxycarbonyl)azetidin-3-ylcarbamoyl)phenoxy)piperidine-1-carboxylate

https://huagongshe.com/reaction/873563

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}benzoic acidHCID 2794649—
Reactant1-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acidHCID 10988214—
Reactanttert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylateHCID 22181157—
ProductTert-butyl 4-(4-(1-(benzyloxycarbonyl)azetidin-3-ylcarbamoyl)phenoxy)piperidine-1-carboxylateHCID 86702039—

Reaction Steps

The title compound was prepared as described in Example 1A, substituting benzyl 3-aminoazetidine-1-carboxylate for tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate and 4-(1-(tert-butoxycarbonyl)piperidin-4-yloxy)benzoic acid for 1-(benzyloxycarbonyl)azetidine-3-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08975398B2
Source datasetuspto-grants-2015_03
ORD IDord-125423e8e4834e758f512ca799f8cada
Source noteuspto-grants-2015_03