HRID873582

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12286

3-Bromopyridine

C5H4BrN

结构：CC(C)(C)OC(=O)N1CCC(Oc2ccc(NC(=O)C3CNC3)cc2)CC1

HCID86702036

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)[C@H]3CCNC3)cc2)CC1

HCID86702068

未命名化合物

PRODUCTS

生成物

结构：Cc1ncccc1N1CC[C@H](C(=O)Nc2ccc(C3CCN(C(=O)OC(C)(C)C)CC3)cc2)C1

HCID86702067

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as described in Example 1C, substituting 3-bromo-2-methylpyridine for 3-bromopyridine and (S)-tert-butyl 4-(4-(pyrrolidine-3-carboxamido)phenyl)piperidine-1-carboxylate for tert-butyl 4-(4-(azetidine-3-carboxamido)phenoxy)piperidine-1-carboxylate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-44255d1f42b2471f882bd63977605955
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08975398B2
来源说明: uspto-grants-2015_03

反应 SMILES

Br[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[NH:8]1[CH2:12][CH2:11][C@H:10]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([CH:22]3[CH2:27][CH2:26][N:25]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:24][CH2:23]3)=[CH:18][CH:17]=2)=[O:14])[CH2:9]1.N1CC(C(NC2C=CC(OC3CCN(C(OC(C)(C)C)=O)CC3)=CC=2)=O)[CH2:36]1>>[CH3:36][C:3]1[C:2]([N:8]2[CH2:12][CH2:11][C@H:10]([C:13]([NH:15][C:16]3[CH:17]=[CH:18][C:19]([CH:22]4[CH2:23][CH2:24][N:25]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:26][CH2:27]4)=[CH:20][CH:21]=3)=[O:14])[CH2:9]2)=[CH:7][CH:6]=[CH:5][N:4]=1