Methylhydrazine → HCID 86702078, compound

HRID 873591Notes

Reaction equation

HRID 873591 reaction equation
[CH:1]1([C:4]#[C:5][C:6]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=2)=O)[CH2:3][CH2:2]1.[CH3:17][NH:18][NH2:19]>CN(C)C=O.O>[CH:1]1([C:4]2[CH:5]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=3)[N:18]([CH3:17])[N:19]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 6061MethylhydrazineHCID 86702077HCID 86702077, compound

Product 1

HCID 86702078HCID 86702078, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
0 °C

Procedure

3-Cyclopropyl-1-(4-nitrophenyl)prop-2-yn-1-one (500 mg, 2.323 mmol) was dissolved in N,N-dimethylformamide (7.75 mL), and the solution was chilled to 0° C. Methylhydrazine (118 mg, 2.56 mmol) was added dropwise. The mixture was stirred overnight at room temperature then diluted with water (25 mL) and stirred for 45 minutes. The resulting precipitate was collected by filtration to give the title compound.

Workup

  1. stirringstirred for 45 minutes
  2. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-8559eeb855294bbd9563ac329d77f94f
Source dataset
uspto-grants-2015_03
Patent number
US08975398B2

Reaction notes

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