2-Aminopyrimidine → HCID 86691079, compound

HRID 873786Notes

Reaction equation

HRID 873786 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)=O.[NH2:11][C:12]1[N:17]=[CH:16][CH:15]=[CH:14][N:13]=1>C(O)C>[BrH:1].[N:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[C:3]1[N:11]=[C:12]2[N:17]=[CH:16][CH:15]=[CH:14][N:13]2[CH:2]=1

Participants

4

Reactant 2

HCID 79782-AminopyrimidineHCID 383842-Bromoacetamidopyridine

Product 1

HCID 86691079HCID 86691079, compoundYield 77.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

2-Bromo-1-pyridin-2-ylethanone (66.1 g; 330 mmol) was dissolved in ethanol (330 mL), 2-aminopyrimidine (31.5 g; 330 mmol) was added thereto, and the mixture was stirred for 17 hours at 70° C. The precipitated crystals were collected by filtration, washed with acetone, and then dried to give 70.7 g of the title compound (yield 77%).

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with acetone
  3. customdried

Sources & evidence

ORD record
ord-8f4a1181901e46f8a271cd984aee632a
Source dataset
uspto-grants-2015_03
Patent number
US08975411B2

Reaction notes

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