HCID 117702727, compound → HCID 117702578, compound

HRID 873805Notes

Reaction equation

HRID 873805 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([NH:10][CH:11]([C:29]2[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=2)[C:12]2[C:13]([C:26]([OH:28])=O)=[N:14][N:15]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=3)[CH:16]=2)[CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:11]([C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)[C:12]3[C:13](=[N:14][N:15]([CH2:17][C:18]4[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=4)[CH:16]=3)[C:26]2=[O:28])[CH:3]=1

Participants

3

Reactant 1

HCID 117702727HCID 117702727, compound

Product 1

HCID 117702578HCID 117702578, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-ylamino)(4-chlorophenyl)methyl)-1-(4-methoxy-benzyl)-1H-pyrazole-3-carboxylic acid (Step 9.5). tR: 4.58 min (HPLC 1); tR: 1.01 min (LC-MS 2); ESI-MS: 495/497 [M+H]+ (LC-MS 2); Rf=0.55 (CH2Cl2/MeOH 9:1).

Sources & evidence

ORD record
ord-126c9088456e4f82b4f42f924be21815
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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