3-fluoro-1-methyl-5-nitropyridin-2(1H)-one → 5-amino-3-fluoro-1-methylpyridin-2(1H)-one

HRID 873813Notes

Reaction equation

HRID 873813 reaction equation
[F:1][C:2]1[C:3](=[O:12])[N:4]([CH3:11])[CH:5]=[C:6]([N+:8]([O-])=O)[CH:7]=1>C(Cl)Cl.CO>[NH2:8][C:6]1[CH:7]=[C:2]([F:1])[C:3](=[O:12])[N:4]([CH3:11])[CH:5]=1

Participants

3

Reactant 1

HCID 1177029793-fluoro-1-methyl-5-nitropyridin-2(1H)-one

Product 1

HCID 1177026115-amino-3-fluoro-1-methylpyridin-2(1H)-one

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 5.2 using 3-fluoro-1-methyl-5-nitropyridin-2(1H)-one (Step 14.1). tR: 0.22 min (LC-MS 2); ESI-MS: 143 [M+H]+ (LC-MS 2); Rf=0.25 (CH2Cl2/MeOH 9:1).

Sources & evidence

ORD record
ord-0e865c11690b4b6ab444a75c2118c079
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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