Dichloromethane methanol → 3-Chloro-5-iodo-1-methylpyridin-2(1H)-one

HRID 873828Notes

Reaction equation

[Cl:1][C:2]1[C:3]([OH:9])=[N:4][CH:5]=[C:6]([I:8])[CH:7]=1.[CH2:10](Cl)Cl.CO>>[Cl:1][C:2]1[C:3](=[O:9])[N:4]([CH3:10])[CH:5]=[C:6]([I:8])[CH:7]=1

Participants

Reactant 2

HCID 21226129Dichloromethane methanol

HCID 178517798HCID 178517798, compound

Product 1

HCID 231159603-Chloro-5-iodo-1-methylpyridin-2(1H)-one

Procedure

The title compound was prepared in analogy to the procedure described in Step 23.2 using 3-chloro-5-iodo-pyridin-2-ol. tR: 3.30 min (HPLC 1); tR: 0.71 min (LC-MS 2); ESI-MS: 270 [M+H]+ (LC-MS 2); Rf=0.79 (CH2Cl2/MeOH 9:1).

Sources & evidence

ORD record: ord-311a7e71d30e4dc686d6c7f1387f5846
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08975417B2

Reaction notes

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