Dichloromethane methanol → HCID 117702786, compound

HRID 873835Notes

Reaction equation

ClC1[CH:7]=[CH:6][C:5]([CH:8]([NH:27][C:28]2[CH:33]=[C:32]([CH3:34])[C:31](=[O:35])[N:30]([CH3:36])[CH:29]=2)[C:9]2[C:10]([C:24](O)=[O:25])=[N:11][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=3)[C:13]=2[CH3:14])=[CH:4][CH:3]=1.[CH2:37]([Cl:39])Cl.CO>>[Cl:39][C:37]1[CH:3]=[CH:4][C:5]([CH:8]2[C:9]3[C:10](=[N:11][N:12]([CH2:15][C:16]4[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=4)[C:13]=3[CH3:14])[C:24](=[O:25])[N:27]2[C:28]2[CH:33]=[C:32]([CH3:34])[C:31](=[O:35])[N:30]([CH3:36])[CH:29]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 21226129Dichloromethane methanol

HCID 117702780HCID 117702780, compound

Product 1

HCID 117702786HCID 117702786, compound

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-ylamino)methyl)-1-(4-methoxybenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid (Step 27.2). tR: 4.54 min (HPLC 1); tR: 1.03 min (LC-MS 2); ESI-MS: 489 [M+H]+ (LC-MS 2); Rf=0.40 (CH2Cl2/MeOH 9:1).

Sources & evidence

ORD record: ord-0218af6b596b4bcfa4dccb9417c77a31
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08975417B2

Reaction notes

Loading…