HCID 117702862, compound → HCID 86294282, compound

HRID 873855Notes

Reaction equation

HRID 873855 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([NH:10][CH:11]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)[C:12]2[C:13]([C:20](O)=[O:21])=[N:14][N:15]([CH:17]3[CH2:19][CH2:18]3)[CH:16]=2)[CH:3]=1>CCOC(C)=O>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:11]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)[C:12]3[C:13](=[N:14][N:15]([CH:17]4[CH2:18][CH2:19]4)[CH:16]=3)[C:20]2=[O:21])[CH:3]=1

Participants

3

Reactant 1

HCID 117702862HCID 117702862, compound

Product 1

HCID 86294282HCID 86294282, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-(((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-cyclopropyl-1H-pyrazole-3-carboxylic acid (Step 37.5). tR: 4.08 min (HPLC 1); tR: 0.92 min (LC-MS 2); ESI-MS: 415 [M+H]+ (LC-MS 2); Rf=0.22 (EtOAc); 1H NMR (400 MHz, DMSO-d6) δ ppm 0.97-1.05 (m, 2H) 1.09-1.15 (m, 2H) 3.43 (s, 3H) 3.84-3.94 (m, 1H) 6.17 (s, 1H) 7.20-7.26 (m, 2H) 7.33-7.38 (m, 2H) 7.87-7.95 (m, 3H).

Sources & evidence

ORD record
ord-c72f3b0e598d47809fb2f02f633b47ac
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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