HCID 117702601, compound → HCID 86294481, compound

HRID 873867Notes

Reaction equation

HRID 873867 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:20][C:21]2[CH:26]=[C:25]([CH3:27])[C:24](=[O:28])[N:23]([CH3:29])[CH:22]=2)[C:9]2[C:10]([C:17]([OH:19])=O)=[N:11][N:12]([CH:14]([CH3:16])[CH3:15])[CH:13]=2)=[CH:4][CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:9]3[C:10](=[N:11][N:12]([CH:14]([CH3:16])[CH3:15])[CH:13]=3)[C:17](=[O:19])[N:20]2[C:21]2[CH:26]=[C:25]([CH3:27])[C:24](=[O:28])[N:23]([CH3:29])[CH:22]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 117702601HCID 117702601, compound

Product 1

HCID 86294481HCID 86294481, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)((1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)amino)methyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid (Step 41.5). tR: 4.05 min (HPLC 1); tR: 0.90 min (LC-MS 2); ESI-MS: 397 [M+H]+ (LC-MS 2); Rf=0.60 (CH2Cl2/MeOH 9:1); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.38-1.47 (m, 6H) 1.90 (s, 3H) 3.34 (s, 3H) 4.54-4.65 (m, 1H) 6.12 (s, 1H) 7.17-7.24 (m, 2H) 7.30-7.39 (m, 3H) 7.69 (d, J=2.7 Hz, 1H) 7.85 (s, 1H).

Sources & evidence

ORD record
ord-93b161ab7a274b16ad3c7ceaabba61a4
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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