HCID 117702761, compound → HCID 86294483, compound

HRID 873872Notes

Reaction equation

HRID 873872 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:24][C:25]2[CH:30]=[C:29]([CH3:31])[C:28](=[O:32])[N:27]([CH3:33])[CH:26]=2)[C:9]2[C:10]([C:21]([OH:23])=O)=[N:11][N:12]([CH:18]3[CH2:20][CH2:19]3)[C:13]=2[C:14]([F:17])([F:16])[F:15])=[CH:4][CH:3]=1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:9]3[C:10](=[N:11][N:12]([CH:18]4[CH2:20][CH2:19]4)[C:13]=3[C:14]([F:16])([F:17])[F:15])[C:21](=[O:23])[N:24]2[C:25]2[CH:30]=[C:29]([CH3:31])[C:28](=[O:32])[N:27]([CH3:33])[CH:26]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 117702761HCID 117702761, compound

Product 1

HCID 86294483HCID 86294483, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)((1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)amino)methyl)-1-cyclopropyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylic acid (Step 43.2) at RT for 30 min. tR: 1.10 min (LC-MS 2); ESI-MS: 463 [M+H]+ (LC-MS 2); Rf=0.43 (CH2Cl2/5% MeOH/1% ammonia); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.08-1.21 (m, 2H) 1.21-1.37 (m, 2H) 1.89 (s, 3H) 3.33 (s, 3H) 3.87-3.97 (m, 1H) 6.32 (s, 1H) 7.23 (d, J=8.6 Hz, 2H) 7.29-7.39 (m, 3H) 7.68 (d, J=2.7 Hz, 1H).

Sources & evidence

ORD record
ord-13a3cc69a8f94ae08334daa485d0b4f4
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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