HCID 117702959, compound → HCID 86294689, compound

HRID 873874Notes

Reaction equation

HRID 873874 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([NH:10][CH:11]([C:27]2[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=2)[C:12]2[C:13]([C:23]([F:26])([F:25])[F:24])=[N:14][N:15]([CH:20]3[CH2:22][CH2:21]3)[C:16]=2[C:17]([OH:19])=O)[CH:3]=1>C(Cl)Cl>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:11]([C:27]3[CH:28]=[CH:29][C:30]([Cl:33])=[CH:31][CH:32]=3)[C:12]3[C:13]([C:23]([F:25])([F:26])[F:24])=[N:14][N:15]([CH:20]4[CH2:21][CH2:22]4)[C:16]=3[C:17]2=[O:19])[CH:3]=1

Participants

3

Reactant 1

HCID 117702959HCID 117702959, compound

Product 1

HCID 86294689HCID 86294689, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-(((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid (Step 44.4).; tR: 1.16 min (LC-MS 2); ESI-MS: 483 [M+H]+ (LC-MS 2); Rf=0.61 (CH2Cl2/5% MeOH); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.08-1.17 (m, 2H) 1.27-1.38 (m, 2H) 3.40 (s, 3H) 3.89-4.09 (m, 1H) 6.27 (s, 1H) 7.25-7.42 (m, 4H) 7.90 (d, J=2.7 Hz, 1H) 7.86 (d, J=2.7 Hz, 1H).

Sources & evidence

ORD record
ord-44dcd3e12ac04f408184c95feb76bcf4
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

Loading…