HCID 117702697, compound → HCID 86294690, compound

HRID 873877Notes

Reaction equation

HRID 873877 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:24][C:25]2[CH:30]=[C:29]([CH3:31])[C:28](=[O:32])[N:27]([CH3:33])[CH:26]=2)[C:9]2[C:10]([C:20]([F:23])([F:22])[F:21])=[N:11][N:12]([CH:17]3[CH2:19][CH2:18]3)[C:13]=2[C:14](O)=[O:15])=[CH:4][CH:3]=1>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:9]3[C:10]([C:20]([F:21])([F:22])[F:23])=[N:11][N:12]([CH:17]4[CH2:19][CH2:18]4)[C:13]=3[C:14](=[O:15])[N:24]2[C:25]2[CH:30]=[C:29]([CH3:31])[C:28](=[O:32])[N:27]([CH3:33])[CH:26]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 117702697HCID 117702697, compound

Product 1

HCID 86294690HCID 86294690, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)((1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)amino)methyl)-1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid (Step 45.2). tR: 1.13 min (LC-MS 2); ESI-MS: 463 [M+H]+ (LC-MS 2); Rf=0.61 (CH2Cl2/5% MeOH); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.07-1.17 (m, 2H) 1.27-1.40 (m, 2H) 1.89 (s, 3H) 3.32 (s, 3H) 3.95-4.05 (m, 1H) 6.24 (s, 1H) 7.21-7.40 (m, 5H) 7.69 (d, J=2.7 Hz, 1H).

Sources & evidence

ORD record
ord-1bf9063b2f64497fbbab982803f4e2bd
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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