HCID 117702614, compound → HCID 86291793, compound

HRID 873892Notes

Reaction equation

HRID 873892 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:28][C:29]2[CH:34]=[C:33]([CH3:35])[C:32](=[O:36])[N:31]([CH3:37])[CH:30]=2)[C:9]2[C:10]([CH3:27])=[N:11][N:12]([C:17]3[C:18]([O:25][CH3:26])=[N:19][C:20]([O:23][CH3:24])=[N:21][CH:22]=3)[C:13]=2[C:14](O)=[O:15])=[CH:4][CH:3]=1>CCOC(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:9]3[C:10]([CH3:27])=[N:11][N:12]([C:17]4[C:18]([O:25][CH3:26])=[N:19][C:20]([O:23][CH3:24])=[N:21][CH:22]=4)[C:13]=3[C:14](=[O:15])[N:28]2[C:29]2[CH:34]=[C:33]([CH3:35])[C:32](=[O:36])[N:31]([CH3:37])[CH:30]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 117702614HCID 117702614, compound

Product 1

HCID 86291793HCID 86291793, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)((1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)amino)methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-3-methyl-1H-pyrazole-5-carboxylic acid (Step 52.4). tR: 4.25 min (HPLC 1); tR: 0.98 min (LC-MS 2); ESI-MS: 507 [M+H]+ (LC-MS 2); Rf=0.11 (EtOAc); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.89 (s, 3H) 1.99 (s, 3H) 3.33 (s, 3H) 3.93 (s, 3H) 3.96 (s, 3H) 6.17 (s, 1H) 7.27-7.32 (m, 2H) 7.34-7.41 (m, 3H) 7.69-7.71 (m, 1H) 8.56 (s, 1H).

Sources & evidence

ORD record
ord-947f1ea23e7d4696a7fdfaf731f75bb5
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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