HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzaldehyde → 5-(3-acetyl-2-(4-chlorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-chloro-1-methyl-pyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzaldehyde | HCID 7726 | — |
| Reactant | Ethyl 2,4-dioxovalerate | HCID 69208 | — |
| Reactant | 5-Amino-3-chloro-1-methyl-1,2-dihydropyridin-2-one | HCID 71756073 | — |
| Product | 5-(3-acetyl-2-(4-chlorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-chloro-1-methyl-pyridin-2(1H)-one | HCID 117702763 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Step 57.1 using 5-amino-3-chloro-1-methylpyridin-2(1H)-one (Step 5.2), 4-chlorobenzaldehyde and ethyl 2,4-dioxovalerate at 120° C. for 1 hr. tR: 3.73 min (HPLC 1); tR: 0.74 min (LC-MS 2); ESI-MS: 393/395 [M+H]+ (LC-MS 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975417B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-9a0e10cc9b0647b48ba1a81976a9345a |
| Source note | uspto-grants-2015_03 |