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HRID873913

反应详情

EQUATION

反应方程式

HRID 873913 的结构方程式

REACTANTS

反应物

3
结构：O=Cc1ccc(Cl)cc1
HCID7726

4-Chlorobenzaldehyde

C7H5ClO

结构：CCOC(=O)C(=O)CC(=O)CC
HCID61590

Ethyl 2,4-dioxohexanoate

C8H12O4

结构：Cc1cc(N)cn(C)c1=O
HCID67456616

未命名化合物

PRODUCTS

生成物

1
结构：CCC(=O)C1C(=O)C(=O)N(c2cc(C)c(=O)n(C)c2)C1c1ccc(Cl)cc1
HCID117702766

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to the procedure described in Step 57.1 using 5-amino-1,3-dimethylpyridin-2(1H)-one (Step 20.2), 4-chlorobenzaldehyde and ethyl 2,4-dioxohexanoate under reflux for 7 hr. The crude product was purified by silica gel chromatography (hexane/CH2Cl2/MeOH 40:60:10 to 0:60:10). tR: 0.82 min (LC-MS 2); ESI-MS: 387 [M+H]+ (LC-MS 2).

WORKUP

后处理

  1. temperatureunder reflux for 7 hr
  2. customThe crude product was purified by silica gel chromatography (hexane/CH2Cl2/MeOH 40:60:10 to 0:60:10)