3,8-Dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-amine → ethyl 4((4-chlorophenyl)((3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)amino)-methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-5-isopropyl-1H-pyrazole-3-carboxylate

HRID 873921Notes

Reaction equation

HRID 873921 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](O)[C:9]2[C:10]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[N:11][N:12]([C:17]3[C:18]([O:25][CH3:26])=[N:19][C:20]([O:23][CH3:24])=[N:21][CH:22]=3)[C:13]=2[CH:14]([CH3:16])[CH3:15])=[CH:4][CH:3]=1.[CH3:33][C:34]1[N:38]2[CH:39]=[C:40]([NH2:44])[CH:41]=[C:42]([CH3:43])[C:37]2=[N:36][N:35]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:44][C:40]2[CH:41]=[C:42]([CH3:43])[C:37]3[N:38]([C:34]([CH3:33])=[N:35][N:36]=3)[CH:39]=2)[C:9]2[C:10]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[N:11][N:12]([C:17]3[C:18]([O:25][CH3:26])=[N:19][C:20]([O:23][CH3:24])=[N:21][CH:22]=3)[C:13]=2[CH:14]([CH3:15])[CH3:16])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 753574493,8-Dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-amineHCID 89602026ethyl 4-((4-chlorophenyl)(hydroxy)methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-5-isopropyl-1H-pyrazole-3-carboxylate

Product 1

HCID 117702746ethyl 4((4-chlorophenyl)((3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)amino)-methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-5-isopropyl-1H-pyrazole-3-carboxylate

Procedure

The title compound was prepared in analogy to the procedure described in Step 10.3 using ethyl 4-((4-chlorophenyl)(hydroxy)methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-5-isopropyl-1H-pyrazole-3-carboxylate (Step 46.11) and 3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-amine (Step 67.4) overnight at RT. tR: 1.02 min (LC-MS 2); ESI-MS: 605 [M+H]+ (LC-MS 2).

Sources & evidence

ORD record
ord-e4f60ca018824310a1900578559d24dc
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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