3,8-Dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-amine → ethyl 4((4-chlorophenyl)((3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)amino)-methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-5-isopropyl-1H-pyrazole-3-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	3,8-Dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-amine	HCID 75357449	—
Reactant	ethyl 4-((4-chlorophenyl)(hydroxy)methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-5-isopropyl-1H-pyrazole-3-carboxylate	HCID 89602026	—
Product	ethyl 4((4-chlorophenyl)((3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)amino)-methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-5-isopropyl-1H-pyrazole-3-carboxylate	HCID 117702746	—

Reaction Steps

The title compound was prepared in analogy to the procedure described in Step 10.3 using ethyl 4-((4-chlorophenyl)(hydroxy)methyl)-1-(2,4-dimethoxypyrimidin-5-yl)-5-isopropyl-1H-pyrazole-3-carboxylate (Step 46.11) and 3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-amine (Step 67.4) overnight at RT. tR: 1.02 min (LC-MS 2); ESI-MS: 605 [M+H]+ (LC-MS 2).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08975417B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-e4f60ca018824310a1900578559d24dc
Source note	uspto-grants-2015_03