HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzaldehyde → 5-(4-Chlorophenyl)-1-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-propionylpyrrolidine-2,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzaldehyde | HCID 7726 | — |
| Reactant | Ethyl-2,4-dioxohexanoate | HCID 61590 | — |
| Reactant | 3,8-Dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-amine | HCID 75357449 | — |
| Product | 5-(4-Chlorophenyl)-1-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-propionylpyrrolidine-2,3-dione | HCID 117702535 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Step 60.1 using 3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-amine (Step 67.4), 4-chlorobenzaldehyde and ethyl 2,4-dioxohexanoate at 110° C. for 4 hr. tR: 0.79 min (LC-MS 2); ESI-MS: 411 [M+H]+, ESI-MS: 409 [M−H]− (LC-MS 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975417B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-fe943cfbb64b427e989c837b385014f6 |
| Source note | uspto-grants-2015_03 |