2-Hydrazinoethanol → HCID 86292189, compound

HRID 873935Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:12]([C:13]3[CH:14]=[C:15]([CH3:23])[C:16]4[O:20][N:19]=[C:18]([CH3:21])[C:17]=4[CH:22]=3)[C:11](=[O:24])[C:10](=O)[CH:9]2[C:26](=O)[CH2:27][CH3:28])=[CH:4][CH:3]=1.[NH:30]([CH2:32][CH2:33][OH:34])[NH2:31]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:9]3[C:26]([CH2:27][CH3:28])=[N:31][N:30]([CH2:32][CH2:33][OH:34])[C:10]=3[C:11](=[O:24])[N:12]2[C:13]2[CH:14]=[C:15]([CH3:23])[C:16]3[O:20][N:19]=[C:18]([CH3:21])[C:17]=3[CH:22]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 80172-Hydrazinoethanol

HCID 117702848HCID 117702848, compound

Product 1

HCID 86292189HCID 86292189, compound

Procedure

The title compound was prepared in analogy to the procedure described in Example 78 using 5-(4-chlorophenyl)-1-(3,7-dimethylbenzo[d]isoxazol-5-yl)-4-propionylpyrrolidine-2,3-dione (Step 79.1) and 2-hydrazinylethanol. The crude material was purified by silica gel chromatography (hexane/EtOAc/MeOH 90:10:1 to 50:50:5 to 0:10:1). tR: 1.10 min (LC-MS 2); ESI-MS: 451 [M+H]+ (LC-MS 2).

Workup

customThe crude material was purified by silica gel chromatography (hexane/EtOAc/MeOH 90:10:1 to 50:50:5 to 0:10:1)

Sources & evidence

ORD record: ord-1230bbe23e9d48fc81be7e94817c66e8
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08975417B2

Reaction notes

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