2-Hydrazinoethanol → HCID 86292588, compound

HRID 873936Notes

Reaction equation

HRID 873936 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:12]([C:13]3[CH:14]=[C:15]([CH3:23])[C:16]4[O:20][N:19]=[C:18]([CH3:21])[C:17]=4[CH:22]=3)[C:11](=[O:24])[C:10](=O)[CH:9]2[C:26](=O)[CH2:27][CH3:28])=[CH:4][CH:3]=1.[NH:30]([CH2:32][CH2:33][OH:34])[NH2:31]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:9]3[C:10](=[N:31][N:30]([CH2:32][CH2:33][OH:34])[C:26]=3[CH2:27][CH3:28])[C:11](=[O:24])[N:12]2[C:13]2[CH:14]=[C:15]([CH3:23])[C:16]3[O:20][N:19]=[C:18]([CH3:21])[C:17]=3[CH:22]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 80172-HydrazinoethanolHCID 117702848HCID 117702848, compound

Product 1

HCID 86292588HCID 86292588, compound

Procedure

The title compound was prepared in analogy to the procedure described in Example 79 using 5-(4-chlorophenyl)-1-(3,7-dimethylbenzo[d]isoxazol-5-yl)-4-propionylpyrrolidine-2,3-dione (Step 9.1) and 2-hydrazinylethanol. tR: 1.04 min (LC-MS 2); ESI-MS: 451 [M+H]+ (LC-MS 2).

Sources & evidence

ORD record
ord-1628e264c1ec4d71a1e1861499c00932
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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