Ethyl 2,4-dioxovalerate → HCID 117702592, compound

HRID 873954Notes

Reaction equation

HRID 873954 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.[F:11][C:12]([F:23])([F:22])[O:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=1.CC[O:26][C:27]([C:29]([CH2:31][C:32]([CH3:34])=[O:33])=[O:30])=O>>[C:32]([CH:31]1[CH:18]([C:17]2[CH:20]=[CH:21][C:14]([O:13][C:12]([F:23])([F:22])[F:11])=[CH:15][CH:16]=2)[N:1]([C:2]2[CH:3]=[C:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=2)[C:27](=[O:26])[C:29]1=[O:30])(=[O:33])[CH3:34]

Participants

4

Reactant 3

HCID 69208Ethyl 2,4-dioxovalerateHCID 69573p-(Trifluoromethoxy)benzaldehydeHCID 674566165-Amino-1,3-dimethyl-1,2-dihydropyridin-2-one

Product 1

HCID 117702592HCID 117702592, compound

Procedure

The title compound was prepared in analogy to the procedure described in Step 57.1 using 5-amino-1,3-dimethylpyridin-2(1H)-one (Step 20.2), 4-trifluoromethoxy-benzaldehyde and ethyl acetopyruvate. tR: 0.79 min (LC-MS 2); ESI-MS: 423 [M+H]+ (LC-MS 2); ESI-MS: 421 [M−H]− (LC-MS 2).

Sources & evidence

ORD record
ord-e5d944eb11b442d7aff64aff8f509d04
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

Loading…