4-(4-chlorophenyl)-5-(4-methoxybenzyl)-3-methyl-1-(1-methyl-1H-pyrazol-5-yl)-4,5-dihydropyrrolo-[3,4-c]pyrazol-6(1H)-one → 4-(4-chlorophenyl)-3-methyl-1-(1-methyl-1H-pyrazol-5-yl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one

HRID 873979Notes

Reaction equation

HRID 873979 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:15]3[C:14]([CH3:16])=[N:13][N:12]([C:17]4[N:21]([CH3:22])[N:20]=[CH:19][CH:18]=4)[C:11]=3[C:10](=[O:23])[N:9]2CC2C=CC(OC)=CC=2)=[CH:4][CH:3]=1>CCOC(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:15]3[C:14]([CH3:16])=[N:13][N:12]([C:17]4[N:21]([CH3:22])[N:20]=[CH:19][CH:18]=4)[C:11]=3[C:10](=[O:23])[NH:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 1177027824-(4-chlorophenyl)-5-(4-methoxybenzyl)-3-methyl-1-(1-methyl-1H-pyrazol-5-yl)-4,5-dihydropyrrolo-[3,4-c]pyrazol-6(1H)-one

Product 1

HCID 1177029454-(4-chlorophenyl)-3-methyl-1-(1-methyl-1H-pyrazol-5-yl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 85.6 using 4-(4-chlorophenyl)-5-(4-methoxybenzyl)-3-methyl-1-(1-methyl-1H-pyrazol-5-yl)-4,5-dihydropyrrolo-[3,4-c]pyrazol-6(1H)-one (Step 114.1). tR: 4.14 min (HPLC 1); tR: 0.92 min (LC-MS 2); ESI-MS: 328 [M+H]+ (LC-MS 2); ESI-MS: 326 [M−H]− (LC-MS 2); Rf=0.61 (EtOAc).

Sources & evidence

ORD record
ord-7119900998124e7e823bc7439c08ec8e
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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