HCID 117702965, compound → HCID 117702700, compound

HRID 873999Notes

Reaction equation

HRID 873999 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:15]3[C:11](=[N:12][N:13]([CH:17]4[CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]4)[C:14]=3[CH3:16])[C:10](=[O:28])[N:9]2[C:29]2[CH:34]=[C:33]([CH3:35])[C:32](=[O:36])[N:31]([CH3:37])[CH:30]=2)=[CH:4][CH:3]=1>C(Cl)Cl.CO>[NH:19]1[CH2:18][CH:17]([N:13]2[C:14]([CH3:16])=[C:15]3[CH:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)[N:9]([C:29]4[CH:34]=[C:33]([CH3:35])[C:32](=[O:36])[N:31]([CH3:37])[CH:30]=4)[C:10](=[O:28])[C:11]3=[N:12]2)[CH2:20]1

Participants

3

Reactant 1

HCID 117702965HCID 117702965, compound

Product 1

HCID 117702700HCID 117702700, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared using an analogous procedure to that described in Step 138.2 using tert-butyl 3-(4-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-3-methyl-6-oxo-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-yl)azetidine-1-carboxylate (Step 138.1 b). tR: 0.61 min (LC-MS 2); ESI-MS: 424.1 [M+H]+ (LC-MS 2); Rf=0.05 (CH2Cl2/MeOH 9:1).

Sources & evidence

ORD record
ord-c6fefd4c66f6498d9d9d21f4266314cb
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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