Hydrochloric Acid → HCID 11642921, compound

HRID 874060Notes

Reaction equation

HRID 874060 reaction equation
[CH3:1][C@@H:2]1[O:4][C@@H:3]1[P:5]([O-:8])([O-:7])=[O:6].[Na+].[Na+].Cl.[CH2:12]1[C@@H:17]([NH2:18])[C@H:16]([O:19][C@H:20]2[O:25][C@H:24]([CH2:26][OH:27])[C@@H:23]([OH:28])[C@H:22]([NH2:29])[C@H:21]2[OH:30])[C@@H:15]([OH:31])[C@H:14]([O:32][C@H:33]2[O:38][C@H:37]([CH2:39][NH2:40])[C@@H:36]([OH:41])[CH2:35][C@H:34]2[NH2:42])[C@H:13]1[NH2:43]>O>[CH3:1][C@@H:2]1[O:4][C@@H:3]1[P:5]([OH:8])([OH:7])=[O:6].[CH2:12]1[C@@H:17]([NH2:18])[C@H:16]([O:19][C@H:20]2[O:25][C@H:24]([CH2:26][OH:27])[C@@H:23]([OH:28])[C@H:22]([NH2:29])[C@H:21]2[OH:30])[C@@H:15]([OH:31])[C@H:14]([O:32][C@H:33]2[O:38][C@H:37]([CH2:39][NH2:40])[C@@H:36]([OH:41])[CH2:35][C@H:34]2[NH2:42])[C@H:13]1[NH2:43]

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 36294TobramycinHCID 73491Disodium [(2R,3S)-3-methyloxiran-2-yl]phosphonate

Product 1

HCID 11642921HCID 11642921, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Fosfomycin disodium (18.057 g, 13.99 g free acid) was dissolved in 250 mL of water and the pH was adjusted to 7.41 by the dropwise addition of 1.53 mL of 4.5 N HCl. To the resulting solution was added 1.56 g of 97.5% tobramycin base. The pH of the solution was adjusted to 7.60 by the addition of 2.45 mL of 4.5 N HCl. The solution was diluted to 500 mL with water and filtered through a 0.2 μm Nalge Nunc 167-0020 membrane filter. The final pH was 7.76, the osmolality was 537 mOsmol/kg, the fosfomycin/tobramycin ratio was calculated to be 9:1, and the chloride concentration was 35.8 mM.

Workup

  1. filtrationfiltered through a 0.2 μm Nalge Nunc 167-0020 membrane
  2. filtrationfilter

Sources & evidence

ORD record
ord-b94d708bab3045eab19343ca81f1f015
Source dataset
uspto-grants-2015_03
Patent number
US08980226B2

Reaction notes

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