Phosphoric Acid → HCID 21812833, compound

HRID 874163Notes

Reaction equation

HRID 874163 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:5]=[CH:4][C:3]=1C#N.P(=O)(O)(O)O.[OH-].[NH4+]>>[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 1004Phosphoric AcidHCID 14923Ammonium HydroxideHCID 123888045-Amino-1-(3-nitrophenyl)-1H-pyrazole-4-carbonitrile

Product 1

HCID 21812833HCID 21812833, compoundYield 80%

Procedure

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole (559 mg, 2.44 mmol) and phosphoric acid (86%, 6 ml) were refluxed at 170° C. for 15 h. The reaction was cooled to room temperature and neutralized with ammonium hydroxide. The organics were extracted three times with diethyl ether (total 40 ml), washed with brine, and dried over magnesium sulfate. Removal of solvent gave 5-amino-1-(3′-nitrophenyl)-pyrazole as a yellow powder (398 mg, 80% yield).

Workup

  1. extractionThe organics were extracted three times with diethyl ether (total 40 ml)
  2. washwashed with brine
  3. dry with materialdried over magnesium sulfate
  4. customRemoval of solvent

Sources & evidence

ORD record
ord-e56ef11a281849f18a2e179f8ec99ee9
Source dataset
uspto-grants-2015_03
Patent number
US08980837B2

Reaction notes

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