Methyl iodide → HCID 178481311, compound

HRID 874169Notes

Reaction equation

HRID 874169 reaction equation
[CH3:1][I:2].[C:3]1([N:9]2[CH:13]=[N:12][CH:11]=[N:10]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(#N)C>[I-:2].[C:3]1([N+:9]2[N:10]=[CH:11][N:12]([CH3:1])[CH:13]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 834321H-1,2,4-Triazole, 1-phenyl-

Product 1

HCID 178481311HCID 178481311, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Procedure

Methyl iodide (0.13 ml; 2 mmol) is added to a solution of 1-phenyl-1,2,4-triazole—which was obtained according to Antilla, J. C. et al., Journal of Organic Chemistry 2004, 69, 5578-5587—(0.15 g; 1 mmol) in 1 ml of acetonitrile. This mixture is heated at 80° C. for 16 hours, and is then evaporated to dryness. The residue obtained is recrystallized from a minimum amount of ethyl acetate, thus making it possible to obtain 0.12 g of the desired product (41%) whose characteristics are the following:

Workup

  1. customwas obtained
  2. customis then evaporated to dryness
  3. customThe residue obtained
  4. customis recrystallized from a minimum amount of ethyl acetate

Sources & evidence

ORD record
ord-ed594b639d0940d9827bb4e09e334c98
Source dataset
uspto-grants-2015_03
Patent number
US08980875B2

Reaction notes

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