Hydrochloric Acid → HCID 67071421, compound

Participants

Reaction Steps

4 M HCl in dioxane (10 ml, 80 mmol) was added to a solution of (±)-(E)-3-[1′-tert-butoxycarbonyl-4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-acrylic acid methyl ester (4.30 g, 11.2 mmol) in DCM (15 ml) and the mixture was stirred at RT for 1 h. The precipitate was filtered off, washed with DCM, dried under vacuum and collected (3.3 g) as a white solid (hydrochloride salt). Y=92%

Provenance & Evidence