Hydrochloric Acid → HCID 67071421, compound

HRID 874222Notes

Reaction equation

HRID 874222 reaction equation
Cl.O1CCOCC1.[CH3:8][O:9][C:10](=[O:35])/[CH:11]=[CH:12]/[C:13]1[CH:14]=[C:15]2[C:31](=[CH:32][CH:33]=1)[O:30][C:18]1([CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19]1)[CH2:17][C:16]2=[O:34]>C(Cl)Cl>[CH3:8][O:9][C:10](=[O:35])/[CH:11]=[CH:12]/[C:13]1[CH:14]=[C:15]2[C:31](=[CH:32][CH:33]=1)[O:30][C:18]1([CH2:22][CH2:21][NH:20][CH2:19]1)[CH2:17][C:16]2=[O:34]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67071620HCID 67071620, compound

Product 1

HCID 67071421HCID 67071421, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4 M HCl in dioxane (10 ml, 80 mmol) was added to a solution of (±)-(E)-3-[1′-tert-butoxycarbonyl-4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-acrylic acid methyl ester (4.30 g, 11.2 mmol) in DCM (15 ml) and the mixture was stirred at RT for 1 h. The precipitate was filtered off, washed with DCM, dried under vacuum and collected (3.3 g) as a white solid (hydrochloride salt). Y=92%

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with DCM
  3. customdried under vacuum
  4. customcollected (3.3 g) as a white solid (hydrochloride salt)

Sources & evidence

ORD record
ord-c122b2b4cd384940ae052e10895ddec9
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

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