Hydrochloric Acid → HCID 67071642, compound

Participants

Reaction Steps

A mixture of (E)-3-{1′-tert-butoxycarbonyl-8-fluoro-4-oxo-spiro[chromane-2,4′-piperidine]-6-yl}-acrylic acid methyl ester (2.78 g, 6.63 mmol) and 4 M HCl in dioxane (3 ml) in DCM (50 ml) was stirred at RT for 5 h. The solvent was removed, the residue was triturated in DCM and filtered to give the title compound as its hydrochloride salt (2.04 g).

Provenance & Evidence